Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder in Candida albicans.
Identifieur interne : 000366 ( Main/Exploration ); précédent : 000365; suivant : 000367Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder in Candida albicans.
Auteurs : Dan Zhang [République populaire de Chine] ; Yijie Dong [République populaire de Chine] ; Qilin Yu [République populaire de Chine] ; Zhang Kai [République populaire de Chine] ; Meng Zhang [République populaire de Chine] ; Chang Jia [République populaire de Chine] ; Chenpeng Xiao [République populaire de Chine] ; Bing Zhang [République populaire de Chine] ; Biao Zhang [République populaire de Chine] ; Mingchun Li [République populaire de Chine]Source :
- Future microbiology [ 1746-0921 ] ; 2017.
Descripteurs français
- KwdFr :
- MESH :
- enzymologie : Candida albicans.
- génétique : Candida albicans, Recombinaison homologue.
- métabolisme : Fer, Glutarédoxines.
- Cycle cellulaire, Délétion de gène, Mutation, Stress oxydatif.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Glutaredoxins, Iron.
- enzymology : Candida albicans.
- genetics : Candida albicans, Homologous Recombination.
- Cell Cycle, Gene Deletion, Mutation, Oxidative Stress.
Abstract
AIM
Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans.
MATERIALS & METHODS
A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The function of Grx3 was investigated by a series of biochemical methods.
RESULTS
Deletion of GRX3 impaired growth and cell cycle, disturbance of iron homeostasis and activated the oxidative stress response. Furthermore, disruption of GRX3 caused oxidative damage and growth defects of C. albicans.
CONCLUSION
Our findings provide new insights into the role of GRX3 in C. albicans.
DOI: 10.2217/fmb-2017-0098
PubMed: 29039220
Affiliations:
Links toward previous steps (curation, corpus...)
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type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Meng" sort="Zhang, Meng" uniqKey="Zhang M" first="Meng" last="Zhang">Meng Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Jia, Chang" sort="Jia, Chang" uniqKey="Jia C" first="Chang" last="Jia">Chang Jia</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Xiao, Chenpeng" sort="Xiao, Chenpeng" uniqKey="Xiao C" first="Chenpeng" last="Xiao">Chenpeng Xiao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Zhang, Biao" sort="Zhang, Biao" uniqKey="Zhang B" first="Biao" last="Zhang">Biao Zhang</name><affiliation wicri:level="1"><nlm:affiliation>College of language and culture, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of language and culture, Tianjin University of Traditional Chinese Medicine, Tianjin 300193</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author><author><name sortKey="Li, Mingchun" sort="Li, Mingchun" uniqKey="Li M" first="Mingchun" last="Li">Mingchun Li</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071</wicri:regionArea><placeName><settlement type="city">Tianjin</settlement></placeName></affiliation></author></analytic><series><title level="j">Future microbiology</title><idno type="eISSN">1746-0921</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Candida albicans (enzymology)</term><term>Candida albicans (genetics)</term><term>Cell Cycle (MeSH)</term><term>Gene Deletion (MeSH)</term><term>Glutaredoxins (metabolism)</term><term>Homologous Recombination (genetics)</term><term>Iron (metabolism)</term><term>Mutation (MeSH)</term><term>Oxidative Stress (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Candida albicans (enzymologie)</term><term>Candida albicans (génétique)</term><term>Cycle cellulaire (MeSH)</term><term>Délétion de gène (MeSH)</term><term>Fer (métabolisme)</term><term>Glutarédoxines (métabolisme)</term><term>Mutation (MeSH)</term><term>Recombinaison homologue (génétique)</term><term>Stress oxydatif (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Glutaredoxins</term><term>Iron</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Candida albicans</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Candida albicans</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Candida albicans</term><term>Homologous Recombination</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Candida albicans</term><term>Recombinaison homologue</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Fer</term><term>Glutarédoxines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Cycle</term><term>Gene Deletion</term><term>Mutation</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cycle cellulaire</term><term>Délétion de gène</term><term>Mutation</term><term>Stress oxydatif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIM</b></p><p>Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIALS & METHODS</b></p><p>A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The function of Grx3 was investigated by a series of biochemical methods.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Deletion of GRX3 impaired growth and cell cycle, disturbance of iron homeostasis and activated the oxidative stress response. Furthermore, disruption of GRX3 caused oxidative damage and growth defects of C. albicans.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>Our findings provide new insights into the role of GRX3 in C. albicans.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29039220</PMID><DateCompleted><Year>2018</Year><Month>07</Month><Day>20</Day></DateCompleted><DateRevised><Year>2018</Year><Month>08</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1746-0921</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><PubDate><Year>2017</Year><Month>11</Month></PubDate></JournalIssue><Title>Future microbiology</Title><ISOAbbreviation>Future Microbiol</ISOAbbreviation></Journal><ArticleTitle>Function of glutaredoxin 3 (Grx3) in oxidative stress response caused by iron homeostasis disorder in Candida albicans.</ArticleTitle><Pagination><MedlinePgn>1397-1412</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2217/fmb-2017-0098</ELocationID><Abstract><AbstractText Label="AIM">Glutaredoxin is a conserved oxidoreductase in eukaryotes and prokaryotes. This study aimed to determine the role of Grx3 in cell survival, iron homeostasis and the oxidative stress response in Candida albicans.</AbstractText><AbstractText Label="MATERIALS & METHODS">A grx3Δ/Δ mutant was obtained using PCR-mediated homologs recombination. The function of Grx3 was investigated by a series of biochemical methods.</AbstractText><AbstractText Label="RESULTS">Deletion of GRX3 impaired growth and cell cycle, disturbance of iron homeostasis and activated the oxidative stress response. Furthermore, disruption of GRX3 caused oxidative damage and growth defects of C. albicans.</AbstractText><AbstractText Label="CONCLUSION">Our findings provide new insights into the role of GRX3 in C. albicans.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Dan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Yijie</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The State Key Laboratory for Biology of Plant Disease & Insect Pests, Institute of Plant protection, Chinese Academy of Agricultural sciences, Beijing 100871, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Qilin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kai</LastName><ForeName>Zhang</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Meng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Chang</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Chenpeng</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Bing</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Biao</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>College of language and culture, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Mingchun</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Key Laboratory of Molecular Microbiology & Technology, Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin 300071, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Future Microbiol</MedlineTA><NlmUniqueID>101278120</NlmUniqueID><ISSNLinking>1746-0913</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054477">Glutaredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>E1UOL152H7</RegistryNumber><NameOfSubstance UI="D007501">Iron</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002176" MajorTopicYN="N">Candida albicans</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002453" MajorTopicYN="N">Cell Cycle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017353" MajorTopicYN="N">Gene Deletion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054477" MajorTopicYN="N">Glutaredoxins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059765" MajorTopicYN="N">Homologous Recombination</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007501" MajorTopicYN="N">Iron</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="Y">Oxidative Stress</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Candida albicans</Keyword><Keyword MajorTopicYN="Y">Grx3</Keyword><Keyword MajorTopicYN="Y">iron homeostasis</Keyword><Keyword MajorTopicYN="Y">oxidative stress response</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>10</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>7</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29039220</ArticleId><ArticleId IdType="doi">10.2217/fmb-2017-0098</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li><li>Tianjin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Dan" sort="Zhang, Dan" uniqKey="Zhang D" first="Dan" last="Zhang">Dan Zhang</name></noRegion><name sortKey="Dong, Yijie" sort="Dong, Yijie" uniqKey="Dong Y" first="Yijie" last="Dong">Yijie Dong</name><name sortKey="Dong, Yijie" sort="Dong, Yijie" uniqKey="Dong Y" first="Yijie" last="Dong">Yijie Dong</name><name sortKey="Jia, Chang" sort="Jia, Chang" uniqKey="Jia C" first="Chang" last="Jia">Chang Jia</name><name sortKey="Kai, Zhang" sort="Kai, Zhang" uniqKey="Kai Z" first="Zhang" last="Kai">Zhang Kai</name><name sortKey="Li, Mingchun" sort="Li, Mingchun" uniqKey="Li M" first="Mingchun" last="Li">Mingchun Li</name><name sortKey="Xiao, Chenpeng" sort="Xiao, Chenpeng" uniqKey="Xiao C" first="Chenpeng" last="Xiao">Chenpeng Xiao</name><name sortKey="Yu, Qilin" sort="Yu, Qilin" uniqKey="Yu Q" first="Qilin" last="Yu">Qilin Yu</name><name sortKey="Zhang, Biao" sort="Zhang, Biao" uniqKey="Zhang B" first="Biao" last="Zhang">Biao Zhang</name><name sortKey="Zhang, Bing" sort="Zhang, Bing" uniqKey="Zhang B" first="Bing" last="Zhang">Bing Zhang</name><name sortKey="Zhang, Meng" sort="Zhang, Meng" uniqKey="Zhang M" first="Meng" last="Zhang">Meng Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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